Objective：To investigate the effect of early drug intervention of Danggui Buxue granules expression of CTGF in Spontaneously Hypertensive RatS（SHR）on renal interstitial fibrosis and renal vascular lesion.Method：SHR were randomly divided into early group and late group.Early group and late group were then divided into danggui buxue granules group（DG group） and normal saline group（ NS group）.Early group was choosed 8 weeks old SHR and late group of 12 weeks old SHR. Normal group was choosed WKY rats at the same age in early and late groups. The rats were treated with DG 6 g/（kg·d）by gastric gavage in DG group and equivalent normal saline by gastric gabage in NS group and WKY rats，the rats were sacrificed at 28 weeks old.Serum creatinine，urea nitrogen and urinary β2 microglobulin were detected.Pathological changes of the renal tissue were observed by HE staining；the mRNA expression of CTGF was detected by real-time PCR， and the protein expression of CTGF was detected by Western Blot.Result：Compared with NS group， early DG group serum creatinine，urea nitrogen ，urinary β2 microglobulin ，the renal interstitial damage index，the degree of vasular lesions ，the expression of CTGF mRNA and CTGF were significantly reduced，the differences were statistically significant（P<0.05）. In late group， compared with NS group，DG group of urinary β2 microglobulin，the renal interstitial damage index， the degree of vasular lesions ，the expression of CTGF mRNA and CTGF reduced， the difference was statistically significant（P<0.01）. The effection in early group was better than late group，DG was no effect on blood pression in SHR（P>0.05）. Conclusion：Early intervention by DG can significantly attenuates renal interstitial fibrosis and renal vascular lesions in SHR by suppressing the expression of CTGF，the effection was no relationship with blood flow dynamics.

2015 Vol. 12　(14):　1-5 [Abstract]（ 596 ） HTML (1 KB)  PDF  (715 KB)  ( 293 )

Objective：To investigate the value of 40% iodized oil parotid duct infusion for chronic parotitis.Method：80 cases with chronic mumps in our hospital from January 2011 to June 2014 were choosed， all patients were confirmed by clinical and pathological biopsy， and then all patients were randomly divided into two groups according random number， 40 cases in each group.The observation group were used 40% iodized oil angiography and treatment，the control group were used only the total amount of injection of 3-5 mL of 76% diatrizoate，then the adverse events and clinical diagnosis between the two groups during the treatment were compared.Result：The observation group during the treatment with parotid gland swelling， severe pain， and increase the proportion of mumps disease were lower than control group， the observation group with clinical diagnosis was higher than control group，the recovery rate was higher than control group，the inefficient of observation group was higher than control group， the differences were statistically significant（P<0.05）.Conclusion：40% iodized oil parotid duct infusion for chronic parotitis has simple operation and good angiography revealed，it is nontoxic and it also has a therapeutic effect.

2015 Vol. 12　(14):　9-12 [Abstract]（ 619 ） HTML (1 KB)  PDF  (685 KB)  ( 820 )

Objective： To study the serum level of carcinoembryonic antigen and whole-body metastasis ability risk in patients with advanced non-small cell lung cancer，and provide the reference for clinical.Method： 160 patients with stage IV NSCLC in our hospital from March 2012 to January 2014 were selected. Research indicators included age，height，weight，age，sex，histological classification，tumor differentiation ，CEA level，smoking status，bone metastases，lymphatic metastasis，obstinate/transfer， transfer， soft tissue of neck metastases， brain metastases， systemic metastasis score and systemic metastasis LN-adjustment score， and the statistical analysis was performed. Result： The sex，bone metastases，histological classification lymph node metastasis and brain metastasis of different CEA level patients had ad statistical significance（ P<0.05），but the age， smoking status， tumor differentiation，obstinate/transfer，transfer， and soft tissue of neck metastases showed no statistical difference（P>0.05）.Serum CEA level increased from 2.7 ng/mL in LN-adjusted whole-body metastatic score 1 to 374.1 ng/mL in LN-adjusted whole-body metastatic score 7，the difference was statistically significant（ P=0.003）.Similarly， the low LN-adjusted whole-body metastatic score （rating 1-3） showed CEA level significantly reduced when compared with adjustment of high LN-adjusted whole-body metastatic score（ rating 4-7），the difference was statistically significant（P<0.001）.Scores of high CEA levels in serum from 37.5%（15/40） in LN-adjusted whole-body metastatic score 1 rose to 100%（1/1） in LN-adjusted whole-body metastatic score 6， the difference was statistically significant（P<0.001）.Similarly， high serum CEA score rose from 25%（ 2/8） in LN-adjusted whole-body metastatic score 1 rose to 100%（1/1） in LN-adjusted whole-body metastatic score 7， the difference was statistically significant（P<0.001）.Univariate analysis results showed that gender， bone metastases， histological classification and lymph node metastases and brain metastasis were risk factors of high CEA level，multivariate Logistic regression analyses showed that the histological classification OR（95% CI）=3.611（1.375-5.313）（P<0.001），bone metastases OR（95% CI）=3.513（1.856-4.637）（P<0.001），and brain metastases OR（95% CI）=3.338（1.271-5.533）（P<0.001）were independent risk factor of the influence of high CEA level. Conclusion： High serum CEA level and systemic metastasis increases with advanced non-small cell lung cancer are closely related. High serum
CEA level is more frequently in bone metastases， brain metastasis， lymph node metastasis and lung metastasis patients.

2015 Vol. 12　(14):　16-19 [Abstract]（ 646 ） HTML (1 KB)  PDF  (686 KB)  ( 383 )

Objective：To investigate the clinical application value of recombinant human erythropoietin on the patients with tumor related anemia.Method：110 patients with malignant tumor anemia were selected as the research object，according to random digit table，they were divided into combined ombined group（ group A， n=60） and control group（ group B， n=50）.The incidence of adverse reactions，clinical curative effect，record count red blood cells（RBC），the level of hemoglobin（Hb） and hematocrit（HCT） variations of two groups before and after treatment were compared.Result：（1）20 cases of group A were markedly effective in 21 cases， clinical total effective rate was 68.3%，was obviously higher than that of groupB 48%， contrast differences were significant（P<0.05）.（2）After the treatment，two groups of patients erythrocyte count， hemoglobin and hematocrit levels were higher than before treatment， growth in groupAwas higher than B group（ P<0.05）.（3）Two groups of patients had no serious adverse reactions occur， in A group， the incidence rate of 63.3% compared to group B 58.0%， difference was not statistically significant（P>0.05）. Conclusion：The curative effect of chemotherapy combined with recombinant human erythropoietin on the patients with tumor related anemia element scheme is exactly， can effectively improve the symptoms of anemia， is worthy of clinical promotion.

2015 Vol. 12　(14):　25-27 [Abstract]（ 598 ） HTML (1 KB)  PDF  (666 KB)  ( 214 )

Objective：To investigate the efficiency of clinical application of super-lizer treatment for patients with degenerative osteoarthritis of the knee. Method：86 patients with degenerative arthritis of the knee were selected from October 2011 to October 2014 in our hospital， these 86 patients were randomly divided into control group and experimental group，43 cases in each group.The control group was treated with conventional therapy，given non-steroidal antiinflammatory therapy based on treatment of protecting the knee， and experimental group was given super lizer treatment based on conventional treatment.The treatment effect， knee function and pain remission of patients in the two groups were compared.Result： The total effective rate of the experimental group was 90.69%，the total effective rate was 72.09% in the control group， the experimental group was better than the control group，the difference was statistically significant（P<0.05）；before treatment，the pain scores of two group of patients was no statistically significant difference（P>0.05）；after treatment， patients’ pain score in the experimental group was significantly lower than the control group， the difference was statistically significant（P<0.05）； before treatment， there was no significantly significant difference between two groups of patients at HSS Compare ratings and WOMAC scores（P>0.05）； after treatment， in both groups， the HSS score and WOMAC scores improved significantly compared with before treatment， the differences were statistically significant（P<0.05）， but the HSS score and WOMAC scores of experiment group of patients were significantly better than the control group， the difference was statistically significant（P<0.05）. Conclusion： Applying super lizer treatment programs in patients with degenerative arthritis of the knee， the analgesic effect is significant， it can promote the recovery of patients with knee function， and has important clinical reference value.

2015 Vol. 12　(14):　31-33 [Abstract]（ 829 ） HTML (1 KB)  PDF  (666 KB)  ( 553 )

Objective：To focus on exploring the value of monitoring the changes of umbilical artery blood flow spectrum for diagnosis of intrauterine growth retardation.Method：52 patients with intrauterine growth retardation who received treatment in our hospital from February 1st，2011 to February 1st， 2014 were chosen as the observation group.At the same time， 52 pregnant women with normal pregnancy were chosen as the control group.The two groups of pregnant women were under the monitoring of color Doppler.The monitoring results of the two groups were compared at last. Result：As the gestational weeks increased， the end diastolic velocity EDV）， peak diastolic velocity（ PDV）， mean flow velocity（MFV） and peak systolic velocity（ PSV） of umbilical artery of the two groups showed rising trend.However， the EDV and PDV of the observation group were much lower than that of control group.The resistance index（RI），pulsatility index（ PI） and ratio of systolic and diastolic（S/D ratio） of the two groups showed a decreasing trend.The RI，PI and S/D ratio of the observation group were still higher than that of the control group.Changes of umbilical artery hemodynamics of pregnant women in the two groups were significantly different（P<0.05）.Conclusion：The early monitoring of changes of umbilical artery blood flow spectrum is helpful to discover the abnormity of umbilical artery blood flow spectrum， which provides reliable basis for the clinical treatment.

2015 Vol. 12　(14):　38-40 [Abstract]（ 560 ） HTML (1 KB)  PDF  (664 KB)  ( 285 )

Objective：To observe the clinical curative effect of B ultrasound guided injection of methotrexate in gestational sac（MTX） with MTX in pregnancy intramuscular injection in treatment of cesarean scar（CSP）. Method：90 cases of pregnancy patients with cesarean scar were selected in our hospital，according to radom digit table， they were divided into the study group and control group.The study group was given therapeutic by ultrasound guided injection in gestational sac MTX， the control group was given intramuscular MTX injection. The clinical cure rate，hospitalization time， blood progesterone； beta human chorionic gonadotropin（ Human Chorionic Gonadotropin， beta-hCG），the changes of pregnancy mass diameter of two groups patients were observed before and after treatment. In addition， adverse reactions of hospitalized patients were observed during the treatment.Result： Clinical cure rate of the study group was 95.45%，the clinical cure rate of control group was 52.17%， the difference was significant（P<0.05）.The average hospitalization time of the study group was（ 7.1±2.0）d，beta-hCG to restore the normal time was（ 26.6±5.6）d，the average hospitalization time of the control group was（ 15.4±3.6）d，beta-hCG to restore the normal time was（ 35.5±3.6）d，there was significant difference（ P<0.05）.Beta-hCG， pregnancy mass diameter of the study group patients after the blood progesterone were（ 4.0±2.1）ng/mL，（315.6±60.6）U/L，（0.5±0.3）cm，the control group were respectively（ 7.9±3.6）ng/mL，（786.3±88.3）U/L，（1.7±0.6）cm，difference were significant（ P<0.05）.Alanine aminotransferase（ALT），nausea and vomiting，elevated white blood cell（ WBC） increased rates of the study group were 25.00%，9.09% and 2.27%， the control group were 54.35%，26.09% and 15.22%，there were significant difference （P<0.05）.Conclusion：B ultrasound guide therapeutic effect of gestational sac injection in the treatment of cesarean scar pregnancy MTX exactly， can rapid onset and had clinical and less adverse reactions，it is worthy of promotion.

2015 Vol. 12　(14):　44-46 [Abstract]（ 661 ） HTML (1 KB)  PDF  (667 KB)  ( 370 )

Objective：To investigate the clinical significance for the serum levels of High Sensitivity C Reactive Protein（hs-CRP），Albumin（ALB）and Fibrinogen（ FIB） in gestational hypertension disease.Method：To select the pregnancy hypertension women（121cases，observational group） and the healthy pregnant women（60 cases，the control group） at the same gestational age in our hospital to determine the serum levels of hs-CRP，ALB，FIB among them，from October 2010 to October 2013.Result：The serum levels of hs-CRP，FIB were higher in observational group than in the control group（P<0.05），the serum levels of ALB were higher in the control group than moderate and severe cases（P<0.05）.Conclusion：The serum levels of hs-CRP，FIB，ALB has clinical significance for diagnose and the judgments of condition severity in gestational hypertension disease.

2015 Vol. 12　(14):　50-51 [Abstract]（ 600 ） HTML (1 KB)  PDF  (645 KB)  ( 295 )

Objective：To investigate efficacy of azithromycin and erythromycin in treatment of mycoplasma pneumonia and the effects on immunoglobulins and T lymphocyte subsets.Method：108 cases of mycoplasma pneumonia in children were selected from our hospital during the period from November 2012 to November 2013，they were randomly divided into observation group and control group in accordance with the treatment order， 54 cases in each group， two groups of children were given cough， fever and other routine treatment， on this basis， the control group were treated with g erythromycin， the observation group were treated with azithromycin， after 4 weeks of treatment， clinical efficacy and adverse reactions of two groups were compared.Result： Total efficiency of the observation group was 96.30%，significantly higher than the 79.63% in control group（P<0.05）.Cooling time，time cough，pulmonary rales disappeared time and average length of stay of the observation group were significantly less than the control group（P<0.05）.IgA，IgG，IgM，CD4+ and CD4+/CD8+ ratio level of the observation group were significantly higher the control group（P<0.05）.The incidence of adverse reactions of the observation group was 5.56%，significantly lower than the control group（P<0.05）. Conclusion：Azithromycin in treatment of mycoplasma pneumonia have significant effect， can effectively improve the clinical symptoms and signs， and the adverse reaction is small， safe， worth promoting and applications in clinical.

2015 Vol. 12　(14):　54-57 [Abstract]（ 799 ） HTML (1 KB)  PDF  (687 KB)  ( 399 )

Objective：To investigate the gene expression of interleukin-10（IL-10） and interferon-γ（IFN-γ） colon tissue and methylation status of the promoter region.Method：Randomly selected from January 2011 to June 2014 colon cancer patient’s tissue 80 cases of colon cancer group， 80 cases of corresponding adjacent tissues as adjacent group，ad 100 cases of normal healthy colon tissue as the control group.Using bisulfite sequencing method（ BSP），methylation specific PCR（MSP） and real-time quantitative PCR（ RT-PCR） detection of promoter methylation of three groups of patients with colonic tissue IL-10 and IFN-γ gene and mRNA expression status. Result：Comparison of the three groups in the tissue IL-10 and IFN-γ mRNA， the differences were statistically significant（P<0.05）. Colon cancer group and adjacent group of IL-10 mRNA were higher than the control group（P<0.05），IFN-γ mRNA were lower than in the control group（P<0.05）.Three groups of IL-10 gene promoter region-110，-185 sites methylation rates，the difference was statistically significant（P<0.05）.Colon cancer group and adjacent group organization of IL-10 gene promoter region-110 were higher than the control group（P<0.05），colon cancer group IL-10 gene promoter region-185 were lower than in the control group（P<0.05）；IFN-γ gene promoter methylation of the colon cancer group>the adjacent group>the control group， the differences were statistically significant（P<0.05）. Conclusion：IL-10 and IFN-γ gene promoter methylation status affect its expression in colon cancer， colon cancer patients in TH2 polarization state， closely related to the development of colon cancer.

2015 Vol. 12　(14):　60-63 [Abstract]（ 698 ） HTML (1 KB)  PDF  (716 KB)  ( 296 )

Objective：To explore group leader responsibility system effect in thoracic surgery scheduling，change the model of nursing， optimize and reorganize ，and improve the utilization of nursing manpower， the greatest extent possible to meet patients needs and improve patients satisfaction nursing.Method： Since January 2013 the team leader responsibility system were used，that was implementing charge nurse-primary group leader-primary nurse vertical management，the liability of supervising quality were extended by charge nurse to head nurse responsible team leader and nurses， detailed division of labor， and strengthen the various job responsibilities，and accountability to the people. Patients’ satisfaction of two modes，quality of nursing，and nurses working pressure were compared.Result：Before and after the implementation of the responsibility of team leader in charge of patient nursing system scheduling mode satisfaction， quality of nursing， nurses operating pressures， patients’ satisfaction and quality of nursing has improved significantly for nursing， nurses working pressure lower than before，the differences were statistically significant（P<0.05）. Conclusion：Implementation group leader’s　responsibility system and scheduling mode improve patients satisfaction of nursing ，improve nursing quality，and reduce the nurse work pressure.

2015 Vol. 12　(14):　66-69 [Abstract]（ 657 ） HTML (1 KB)  PDF  (686 KB)  ( 215 )

Objective：To explore the case tracking methodology in the patient care in acute respiratory diseases. Method：The case tracking method was adopted， 60 ward patients with severe disease were selected from January 2012 to December 2014，combined with specific cases， accorded to the nursing process of article 14， by means of critically ill patients with a full range of tracked and analyzed，a real critical patients’ nursing problems in the whole process was discovered，and quality improvement was continued.Result：Through rounds， could improved the nurse clinical thinking，development of nursing profession level improved， patients got better care， patient satisfaction was improved， the differences were statistically significant（P<0.05）.Conclusion：Tracking methodology applied in the critically ill disease cases nursing ward round，can cultivate and improve comprehensive clinical nursing ability，critical illness patients get better care，reduce complications， reduce the hospitalization days，and obtain good social benefits.

2015 Vol. 12　(14):　73-76 [Abstract]（ 610 ） HTML (1 KB)  PDF  (686 KB)  ( 469 )

Objective：To observe the application effect analysis of flexible mode nursing management in the hospital based on quality nursing care.Method：In our hospital from January 2011 to December 2012， make the implementation of flexible management mode based on the quality nursing， sum up problems in hospital， put forward relevant management measures， make comparison about the quality of nursing before and after the implementation. Result：Through the implementation of the flexible management，the clinical nursing quality check significantly improved （P<0.05），patient satisfaction with nursing improved significantly after the implementation ， there was significant difference（P<0.05）.Satisfaction of nurses on nursing work after the implementation was 97.07%，it was significantly higher than 70.48% before the implementation，there was significant difference（P<0.05）.After the implementation，nursing staff turnover rate was 5.85%，it significantly decreased compared with the prior implementation of 19.54%，there was significant difference （P<0.05）. Conclusion：The flexible management model based on quality of nursing care can effectively improve the quality of hospital care，improve patient satisfaction for the medical and nursing work in hospital，make effective protection of medical work in the hospital.

2015 Vol. 12　(14):　79-82 [Abstract]（ 607 ） HTML (1 KB)  PDF  (686 KB)  ( 266 )

Objective： To research the efficacy of the deep breath and cough training for the patients with acute myocardial infarction.Method：The clinical data of the 86 patients with acute myocardial infarction who came to our hospital for treatment from April 2013 to April 2014 was collected. Basing on the principle of random number， all the 86 patients were treated by operation and divided into two groups， the observation group and control group，43 patients in each group. The patients in the control group were given regular training while the patients in the observation group were given training of deep breath and cough on the basis of regular training. The cardiac function classification， length of stay， Barther index， ventricular arrhythmias and reoccurrence of myocardial infarction of the two groups of patients were compared. Result：（1）The cardiac function of the patients in observation group improved better than that of control group， which was statistically significant（P<0.05）.（2）Comparing with the control group， the length of stay of the patients in observation group was shorter with higher Barther index. The difference between the two groups was statistically significant（P<0.05）.（3）Ventricular arrhythmias and reoccurrence of myocardial infarction of the observation group were respectively 6.98% and 4.65% while that of the control group were respectively 9.30% and 13.95%. There was not too much difference in ventricular arrhythmias between the two groups so it had not statistical significance（P>0.05）. Reoccurrence of myocardial infarction of the observation group was lower than that of the control group， which was statistically significant（P<0.05）.Conclusion：Through giving training of deep breath and cough to the patients with acute myocardial infarction， their cardiac function can be improved， reoccurrence of myocardial infarction can be lowered and the ventricular arrhythmias can be controlled. It is worth application and population.

2015 Vol. 12　(14):　85-88 [Abstract]（ 527 ） HTML (1 KB)  PDF  (685 KB)  ( 235 )

Objective：To explore the influence of the cognitive behavior therapy（CBT） for cancer pain. Method：72 patients including with cancer pain were inrolled in the study， and divided into 42 cases and 30 controls. The CBT was conducted on the 42 cases， but not the controls.The numeric rating scale（ NRS） and/or verbal rating scale（VRS） were used to determine the severity of cancer pain.Result：After the intervention of CBT，the cases’ pain was obviously relieved，and the effective rate of the cases was 80.95% in three days， otherwise，the controls was 50.00%. Conclusion：CBT aims to change the patients’ irrational beliefs， to improve the cognitions of the disease and cancer pain subjectively. So it can relive the pain apparently，and improve the cancer pain treatment efficiency.

2015 Vol. 12　(14):　92-95 [Abstract]（ 598 ） HTML (1 KB)  PDF  (698 KB)  ( 297 )

Objective：To explore TCM physique characteristics and related effects of perimenopausal female patients with cervical vertebra disease factors.Method：Cervical spondylopathy of perimenopausal women of 200 cases and healthy control women of 96 cases were randomly selected from Guangdong second traditional Chinese medical hospital，the research objects were determined by the institute of Chinese medicine in April 2009 promulgation of the Chinese constitution classification and determination of standard’s constitution，multi factor Logistic regression model was used to analyze the relationship between TCM constitutional types and perimenopausal women with cervical spondylopathy. Result：196 cases of cervical spondylosis patients， peace constitution of 51 cases， the biased constitution of 145 cases，among them， only the biased constitution（ only one biased constitution）of 91 cases， and clip the biased constitution （two or more than two kinds of biased constitution）of 54 cases.96 cases of healthy perimenopausal women， peace constitution of 35 cases， the biased constitution of 61 cases（ all simple biased matter）.The peace constitution proportion of perimenopausal women with cervical spondylopathy was lower than physical health women， and cervical vertebra disease of female biased physique proportion was higher than physical health women， compared two groups’ TCM constitution distribution，the difference was statistically significant（P=0.004）.Logistic regression analysis showed that：compared with the peace constitution， yang deficiency constitution of perimenopausal women suffering from cervical vertebra disease risk increased significantly， the OR value was 1.329.Conclusion：Perimenopausal patients with cervical spondylosis，biased constitution accounted for the vast majority，and from that the yang deficiency constitution in most patients； yang deficiency constitution is positively associated with menopausal women with physical type of cervical spondylosis.

2015 Vol. 12　(14):　98-101 [Abstract]（ 563 ） HTML (1 KB)  PDF  (696 KB)  ( 326 )

Objective：To observe the clinical effect of Sanjie Xiaoying Decoction in the treatment of nodular goiter.Method：According to randomized single blind control method， 120 cases of nodular goiter were divided into two groups， 60 cases in the treatment group were given Sanjie Xiaoying Decoction and euthyrox treatment， control of 60 cases were treated with euthyrox therapy.In January as a course， 3 courses were observed. The observation group before and after treatment and between groups after the treatment of thyroid tumor maximum diameter， goiter symptoms score， the overall effect of change and the group FT3， FT4， TSH. Result：The total effective rate in the treatment group was 83.3%，the total efficiency of control group was 65.0%，the two groups had significant difference（P<0.05）； the two groups after treatment of goiter symptoms scores decreased，compared with the group before treatment， the difference was significant（P<0.05），the treatment group therapy goiter in symptom scores than the control group after treatment decreased significantly，the difference was significant（P<0.05）；the two group after treatment，the maximum diameter of goiter were reduced compared with the group before treatment，the difference was significant（P<0.05），the treatment group after treatment compared with the maximum diameter of goiter the control group after treatment reduced significantly，the difference was significant（P<0.05）.Conclusion：Sanjie Xiaoying Decoction reduce obviously nodular goiter.

2015 Vol. 12　(14):　104-106 [Abstract]（ 516 ） HTML (1 KB)  PDF  (666 KB)  ( 332 )

Objective：To analyze the cause of newborn’s scleredema warm region.Method：93 cases of newborn’s scleroderma of the warm area（ 53 males and 40 females）were collected from January 2011 to June 2014 in our hospital pediatric clinic diagnosed，statistical analysis was performed on all children on admission season and disease，simultaneous detection of clinically relevant indicators in children.Children were divided into mild group of 76 cases and severe group of 17 cases.Preterm children（ included low birth weight） were compared with term children， infection with non-infected， as well as other relevant factors， such as the occurrence of induced scleroderma.Result：After treatment of the disease in children with all different seasons statistics， we could see in warm areas the incidence of newborn mild and severe groups were not affected by winter temperatures， each the number of seasonal incidence of mild and severe remained unchanged（ incidence of children with mild group every season which averaged 19 cases， the average number of children with severe group’s incidence of 4 cases）. There shock and pulmonary bleeding in children were relatively more， the number of male children with 16 cases slightly higher than the number of female children of 14 cases， all total of 30 cases，therefore， there were shock and pulmonary hemorrhage some impact on neonates. Checked small number of children with symptoms of DIC， the difference was not statistically significant（ P>0.05）.All children with clinical response statistics showed that the number of mild children were all significantly higher than children with severe， mild preterm of 58 cases were significantly higher than that of 14 cases of severe preterm， mild infection children of 47 cases were significantly higher than that children with severe infection of 12 cases.Preterm children and children with mild infections surpassed majority.In the group of children with mild， full-term children， the non-infected children， asphyxia children and nonobvious symptoms of asphyxia proportion of children were more than severe group.All patients in the clinical reflected differences were statistically significant（P<0.05）. Conclusion：The main causes of newborn warm regions can be from children with infection， shock， and pulmonary hemorrhage and other factors concerned， no seasonality， which for preterm children（ including low birth weight） that pay more attention to high-risk groups， and give timely treatment.

2015 Vol. 12　(14):　110-112 [Abstract]（ 503 ） HTML (1 KB)  PDF  (665 KB)  ( 273 )

Objective：To investigate the factors of newborn hearing screeningfalse positive and the clinical effect of review rate.Method：The related data analysis of 4080 cases of newborn in our hospital were selected， hearing screening of all newborns， the screening of 436 cases of neonatal fail as the experimental group，set before the study by screening 436 cases as the control group， two groups were compared the results of the review.Result：Six newborns in each group had 680 cases，A group of 110 cases without going through screening， and 81 cases were false-positive； B group of 95 cases without screening，57 cases were false-positive； C group of 67 cases screening were not passed， 40 cases were falsepositive；D group of 78 cases without screening， 62 cases were false-positive； E group of 49 patients without screening，24 cases were false-positive； F group， 37 cases without screening， 18 cases were false-positive.In the experimental group 349 cases for review， the review was 80.1% higher than the control group， the difference was statistically significant（P<0.05）.Conclusion：Hearing screening is an important means of early intervention of hearing disorders， clinical early detection， to strengthen publicity and education improve the rate of neonatal review.

2015 Vol. 12　(14):　115-117 [Abstract]（ 708 ） HTML (1 KB)  PDF  (665 KB)  ( 661 )

Objective：To compare the outpatient antibiotics use and rationality in 2010 and 2014，which reflect the outcome of The Special Rectification Activities of Clinical Use of Antibiotics in our hospital.Method： A retrospective study was made through randomly collecting five thousand prescriptions in two years before and after The Special Rectification Activities of Clinical Use of Antibiotics， to analysis the use of outpatient antibiotics in our hospital about the variety of antimicrobial agents， usage rate，DDDs and DUI for each drug， the reasonableness of antibiotics， et al. Result：The usage rate of outpatients antibiotics and the numbers of irrational prescriptions，significantly decreased in 2014 compared with pre-rectification in 2010；the condition of DUI for single drug was rarely seen in 2014. Conclusion：After The Special Rectification Activities of Clinical Use of Antibiotics，the use of antimicrobial agents in outpatient gradually standardized；the consumption of antimicrobial agents and unreasonable proportions were significantly reduced.

2015 Vol. 12　(14):　121-123 [Abstract]（ 621 ） HTML (1 KB)  PDF  (655 KB)  ( 223 )

Objective：To explore the clinical effects of precise liver resection method in hepatolithiasis.Method：86 cases with hepatolithus underwent hepatectomy from Octomber 2012 to December 2014 were reviewed retrospectively.Result：Operative time was（ 242±42.2）min， blood loss was（ 312±64.3）mL， hospital stay was （16.4±4.2）d， among the patients， 2 cases of bile leakage， 1 case infection of the wound，5 case of pleural effusion，all patients were cured.The time following-up activities were 1 to 24 months，2 cases of recurrence stones.Conclusion：Precise liver resection method is an effective treatment for choledochotomy with a low rate of complications and recurrent stone，it is worth of clinical application.

2015 Vol. 12　(14):　127-129 [Abstract]（ 569 ） HTML (1 KB)  PDF  (653 KB)  ( 256 )

Objective： To analyze the differences between color Doppler flow imaging（ CDFI） and contrast enhanced ultrasound ，to explore their values in the detection of hepatic artery complications after liver transplantation. Method： 136 cases of liver transplantation patients were examined by color Doppler flow imaging， and to observe if the blood perfusion of hepatic artery and hepatic parenchyma was abnormal. Among them 38 cases with color Doppler flow imaging was suspected abnormalities， then using CPS imaging techniques， namely SonoVue and contrast-enhanced ultrasound imaging techniques to examine. Result： In all the 136 cases，The hepatic artery doppler blood flow signals of 98 patients showed clearly ， accounting for 72.06% of the total number，CDFI can't rule out of the HAT for the 38 cases with early postoperative and multiple section scan. After contrast-enhanced ultrasound，6 patients’ liver artery trunk and branch line were normal and showed clearly.1 patient’s hepatic arterial blood flow signals were not showed clearly 1 week after postoperative，11 days later， the patient was confirmed as HAT with contrast-enhanced ultrasound diagnosis. 1 patient’s CDFI showed intrahepatic echo clutter（ in 10 months） and multiple echo of the border area， the final clinical diagnosis was HAT with diffuse infarction of the liver . Conclusion： CDFI and contrast-enhanced ultrasound can be complementary. They can improve the accuracy of diagnosis of hepatic artery complications after liver transplantation effect.

2015 Vol. 12　(14):　133-135 [Abstract]（ 572 ） HTML (1 KB)  PDF  (676 KB)  ( 320 )

Objective：To investigate the effect of VSD combined with burn surgical technology for the treatment of　large area of skin avulsion injury.Method：13 patients with large area of skin avulsion injury were included in our department from September 2012 to October 2014.According to the characteristic of injury condition were treated in emergency surgical debridement，the VSD combined with burn surgical　technology，open wound granulation tissue were cultured，skin graft and transferb of skin flap.The length of healig， physical appearance，function recovery were observed. Result：The wound of 13 patients were cured satisfactorily with little scar by VSD combined with burn surgical technology，their function had been trained to its maximum potential.Conclusion：The methods of VSD combined with burn surgical technology for the treatment of large area of skin avulsion injury is an effective treatment.It is worth popularizing in basiclevel hospitals.

2015 Vol. 12　(14):　139-141 [Abstract]（ 571 ） HTML (1 KB)  PDF  (707 KB)  ( 339 )

Objective： To analysis the clinical value of serum procalcitonin in critically ill patients’ infection diagnosis. Method：150 cases of critically ill patients were chose from July 2011 to July 2014 in our hospital， according to the results of microbiological culture of blood the patients were divided into infected group and non-infected group，patients’ serum procalcitonin and C-reactive protein at the same time were detected， the two indicators of infection in critically ill patients with early diagnostic specificity and sensitivity were compared.Result： The CRP and PCT levels of patients in infected group were significantly higher than non-infected group， the difference was statistically significant（P<0.01）； CRP testing in the diagnosis of patients with severe infection， the specificity was 20.37%（ 11/54）and the sensitivity was 64.58%（62/96）；PCT in the diagnosis of patients with severe infection， the specificity was 46.29%（25/54），and sensitivity was 84.37%（81/96）； PCT detection and early diagnosis in critically ill patients of the specificity and sensitivity were higher than CRP testing， the difference was statistically significant（P<0.05）. Conclusion：Serum PCT and CRP levels in critically ill patients all infected increased， serum PCT detect infection in critically ill patients with a diagnosis of sensitivity and specificity is significantly higher than CRP testing， it can be used for early diagnosis of infection in critically ill patients and treatment.

2015 Vol. 12　(14):　145-147 [Abstract]（ 605 ） HTML (1 KB)  PDF  (666 KB)  ( 185 )

A lot of researches have shown that ox-LDL is an independent factor of coronary heart disease， and this review will introduce the relationship between ox-LDL and coronary heart disease in above aspects， such as the source of ox-LDL， ox-LDL related receptors， immunologic adjustment of ox-LDL.

2015 Vol. 12　(14):　150-152 [Abstract]（ 471 ） HTML (1 KB)  PDF  (655 KB)  ( 355 )