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ZHAO Xiao-rong，WU Ji-zhou.
Objective：To explore the expression and significance of IL-22 in HBV related liver diseases.Method：Whole vein blood was obtained from healthy control（HC）（n=25）and experimental groups including thepatients with asymptomatic carrier（ASC）（n=30），chronic hepatitis B（CHB）（n=40），liver cirrhosis（LC）（n=45），hepatocellular carcinoma（HCC）（n=30）.The level of serum IL-22 were analysed by ELISA.Statistical analysis of the relevance of IL-22 levels and AFP was performed.Result：IL-22 level in the CHB group，LC group， and the HCC group were higher than that in the healthy control（ P=0.010，0.003，0.000）.IL-22 levels had no correlation with AFP.Conclusion：IL-22 may contributed to the occurrence and the development of liver fibrosis and hepatocellular carcinoma.
2015 Vol. 12 (12): 1-3 [Abstract]（
573
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JIA Wen-bin，SUN Xin，DU Zhi-jie，et al.
Objective：To study the effects of artemisine on proliferation and apoptosis of human colon cancer HCT116 and HT29 cells.Method：Human colon cancer cells were treated with artemisine at different concentrations. MTT assay was used to test cell proliferation and FCM was used to detect cell apoptosis.Result：The inhibition rates had upwarded trend with increasing concentrations（ HCT116：19.42%，24.59%，44.84%，74.15%，92.87%；HT29：11.77%，17.63%，34.23%，48.51%，70.59%）， when treated with artemisine at difierent concentrations（ 7.5， 15，30， 60， 120 μg/mL） for 48 hours.Apoptosis rates gradually increased with increasing concentration（ HCT116：2.46%，51.36%，64.10%；HT29：1.14%，35.95%，43.45%）， when treated with artemisine at different concentrations（ 0， 60，120 μg/mL） for 24 hours.Conclusion：Artemisine inhibits proliferation and induces apoptosis of human colon cancer cells HCT116 and HT29.
2015 Vol. 12 (12): 4-7 [Abstract]（
720
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JIANG Li-yan，YU Zhi-pu，SONG Bo.
Objective：To observe the effect of Euphorbia fischeriana polysaccharide（ EFP-AW1） on the P-selectin expression in HUVECs induced by TNF-α. Method：HUVECs were divided into normal group，TNF-α stimulation group and EFP-AW1 and TNF-α associated stimulation group.Flow cytometry was used to measure the level of P-selectin protein in HUVECs cell； and Real-time PCR were applied to assay status of P-selectin mRNA expression in HUVECs cell.Result：TNF-α stimulation group had significantly increased the levels of P-selectin mRNA and protein（P<0.05）. Compared with the group stimulated of TNF-α，the expression of P-selectin mRNA and protein in HUVECs cell had apparently decreased by pre-treated with EFP-AW1（P<0.05），and had a certain dose dependent.Conclusion：EFPAW1 could inhibit the expression of P-selectin induced by TNF-α in endothelial cells.
2015 Vol. 12 (12): 8-10 [Abstract]（
447
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HUANG Yi-yu.
Objective： To explore the primary dysmenorrhea in patients with peripheral blood cell factor and PGF2 alpha and its clinical significance. Method： 50 cases of primary dysmenorrhea from November 2011 to November 2013 in our department were selected as the observation group， 50 cases of healthy female menstrual period over the same period in our hospital the examination were selected as the control group. Used enzyme-linked immunosorbent test（ ELISA） changes of two groups of female menstruation method of peripheral blood cytokines and PGF2 alpha were measured， and IL-10，through IFN-r， PGF2 alpha change between the two groups were compared. Result： The observation group was within 1 weeks before， by IL-4， no significant change of IL-5（ P> 0.05）， while the IL-10， IFN-r， PGF2 in the alpha level than the former（ P<0.05）. Before 1 weeks the IL-4， IL-5， IL-10， IFN-r of the control group had no significant change （P> 0.05）， but the PGF2 alpha level was higher than before（ P<0.05）. The observation group’s IL-5， IL-10，IFN-r，PGF2 levels were significantly higher than those in control group（P<0.05）.Conclusion： Primary dysmenorrhea and the pathogenesis of PGF2 alpha secretion，peripheral blood cell factors， cytokines in peripheral blood in patients with primary dysmenorrhea in vivo and PGF2 levels will appear abnormal changes in PGF2 secretion， and has a certain relationship with cell immune factor.
2015 Vol. 12 (12): 11-14 [Abstract]（
757
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WANG Yi-peng，PENG Bao-kun， ZHU Li-qin，et al.
Objective：To investigate the correlation of gene polymorphism Cytotoxic T lymphocyteassociated Antigen4（ CTLA-4）at position 49 in exon 1 codon 17 with autoimmune thyroid disease（ AITD）.Method：The gene polymorphism CTLA-4 at position 49 in exon 1 codon 17 were conducted using polymerase chain reaction with sequence specific primers in the specimen of peripheral blood.82 patients with Graves disease（ GD） and 51 patients with Hashimoto’s thyroiditis（ HT） were recruited.80 healthy volunteers constituted the control group. Result：The gene frequencies of CTLA-4 at position 49 in exon 1 codon 17 GG genotype and G alleles were significantly higher in GD group than in control group（χ2=9.353，P=0.009；χ2=7.548，P=0.006）.The gene frequencies of CTLA-4 at position 49 in exon 1 codon 17 GG genotype and G alleles were not significantly different in HT group and control group（ χ2=0.062，P=0.969； χ2=0.046，P=0.830）.Conclusion：The gene polymorphism CTLA-4 at position 49 in exon 1 codon 17 may be an independent risk factor for AITD.
2015 Vol. 12 (12): 14-17 [Abstract]（
599
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KANG Bin， CHEN Shu-tao， FENG Jin-ping.
Objective： To study the relationship between collagen degradation in vascular remodeling and instability of coronary atherosclerosis plaque.Method： 131 inpatients who hade been through the coronary angiography exmination were selected. There were 171 patients with coronary angiography exmination ≥ 50%，
they were myocardial infarction（n=39，AMI group）， unstable angina pectoris（n=54，UAP group）， stable angina pectoris（n=24，SAP group），respectively. 14 patients with coronary atherosclerosis<50%. make up the control group. The concentrates of matrix metalloproteinases in serum-9 （MM-9）， tissue inhibitor of matrix metalloproteinase-1（ IMP-1）， MMP-9/TIMP-1 and I-Collagen carboxy terminal telopeptide（ ICTP） were analyzed by enzyme immunoassay. Result： The concentrates of MMP-9 were （270.42±37.64） μg/L，（201.24±28.20） μg/L，（ 142.65±18.62） μg/L and（ 139.28±16.85） μg/L for groups AMI， UAP， SAP and C， respectively. The concentrates of TIMP-1 were（ 264.56±26.18） μg/L，（ 245.07±21.50） μg/L,（ 208.89±31.94） μg/L and（ 197.69±28.52） μg/L， for groups AMI， UAP SAP and C， respectively. The concentrates of ICTP were（ 10.89±0.78） μg/L，（ 9.35±0.61） μg/L，（ 3.97±0.31） μg/L and（ 3.96±0.32） μg/L for groups AMI，UAP， SAP and C， respectively. The concentrates ratios of MMP-9/TIMP-1 were（ 1.020±0.077），（ 0.820±0.057），（0.700±0.060） and（ 0.700±0.090） for groups AMI， UAP， SAP and C， respectively. The above data suggests that the collagen metabolism increase with the aggravation of disease。The concentrate divergences of MMP-9， TIMP-1，MMP-9/TIMP-1 and ICTP between group C and SAP had no statistically meaning（ P>0.05）. The concentrates divergences of MMP-9， TIMP-1， MMP-9/TIMP-1 and ICTP between groups SAP and UAP， groups UAP and AMI had statistically meaning （P<0.05）.Conclusion： The progress of oronary arterial remodeling and vulnerability plate rupture with collagen degradation. The concentrates ratios of MMP-9/TIMP-1 and the concentrates of ICTP in serum may be the indexes for evaluating the instability about unstable plaque of coronary heart disease.
2015 Vol. 12 (12): 18-21 [Abstract]（
631
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XU Yun-jun， LI Xing-yue， LU Xin-lin，et al.
Objective：To show the anatomy of left coronary artery in rats and discuss the advantage of the death rate， success rate and stability of myocardial infarction model through ligating of the coronary artery under staining guidance.Method：8 heart harvested from sacrificed rat and irrigated coronary artery with saline injection after aortic intubation.The best concentration of agarose gel were identified， 1%， 2%， 3% and 4% agarose gel were used to perfuse aortic root at 37 ℃ .101 male rats were perfused to show the anatomy of left coronary artery， then made ligation strategies though analyzed coronary artery distribution， and compared the advantages and disadvantages in death rate，success rate and advantage of stability between high and low ligation.Result：It showed the coronary artery clearly though aortic perfusion by 2% agarose gel at 37 ℃， and the coronary anatomy can mainly be classified into 4 groups.We had made stable myocardial infarction model both in high and low ligation.Conclusion：The method of ligation of the coronary artery under staining guidance can produce stable rat myocardial infarction model both in large and middle infarct size.
2015 Vol. 12 (12): 22-25 [Abstract]（
590
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ZHANG Hong， QI Chao， QIAN Bei， et al.
Objective：To observe the effect of the transient receptor potential vanilloid loid 1（ TRPV1） on neuronal regeneration after crush injury to the rat’s sciatic nerve.Method：The right sciatic nerve of the adult male Sprague-Dawley rats were crushed.Rats in the experimental group received a subcutaneous injection of AMG-517 ，a highly potent and selective TRPV1 antagonist， into the right hind paw 1 h before the crush.At the crush zone， proximal zone and distal zone，the numbers of myelinated fibers on the transverse section were counted after a surviving time of 7 or 14 days. Result：（1）At the intact side and the proximal zone，the numbers of myelinated fibers did not show any difference.（2） the sciatic nerve injury in the middle of neural axon number counting found that damage to 1 week compared with in 2 weeks， AMG517 treatment+1 week after injury compared with 2 weeks， pure injury and compared between AMG517 + damage， its axon number difference had statistical significance（ P<0.01）.Use AMG517 treatment group rats sciatic nerve injury of axon number significantly more than the simple injury group.（3） In the distal sciatic nerve injury， the nerve axon number of damage extended axon number increased with time，especially the damage before used AMG517 treatment group rats damage distal nerve axon number increased obviously， the difference was statistically significant（ P<0.01）.Conclusion：Blockage of the TRPV1 can promote neuronal regeneration after sciatic crush injury.
2015 Vol. 12 (12): 26-30 [Abstract]（
492
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WU Xuan， WANG Xin，CHEN Yun-huan，et al.
Objective：To discuss the influence of Buyanghuanwu decoction on the expression of TNF-ɑ，IL-6，CRP in MCAO rats.Method：60 rats were divided into four groups：control group， model group，low-dose of Buyanghuanwu decoction group and high-dose of Buyanghuanwu decoction group.Motor nerve function of rat was evaluated by using Garcia JH score ，serum TNF-ɑ，IL-6 were detected by using bioluminescence and serum CRP were detected by using immunoturbidimetry.Result：7 days after surgery，compared with model group， nerve function of rats recovered in low-dose group and high-dose group，with significant difference（P<0.05）.There was significant difference between low-dose group and high-dose group（P<0.05）.Compared with model group，there was significant difference of TNF-ɑ in low-dose group and high-dose group（P<0.05）.Compared with model group，there was no difference of IL-6，CRP in low-dose group（P>0.05） ，with significant difference in high-dose group（P<0.05） .Conclusion：In order to protect nerve function，Buyanghuanwu decoction can reduce TNF-ɑ，IL-6，CRP and relieve inflammation.
2015 Vol. 12 (12): 30-32 [Abstract]（
360
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YANG Xiao-dong，MA Xue-mei，SUN Yun-hui.
Objective：To investigate the expression of IL-27 and LTB4 and its clinical significance in non-small cell lung cancer.Method：The expression levels of IL-27 and LTB4 were determined by Immunohistochemical SP method，in 60 cases of non-small cell lung cancer and normal lung tissue.Result：Total positive expression rates of IL-27 and LTB4 were 41.67%， 63.33%， the positive rate of various detection indicators between lung cancer and the control group were different（ P<0.05）.The expression of IL-27 and LTB4 were related with the degree of tumor differentiation（ P<0.05），The expression of IL-27 was related with TNM stage of lung cancer（ P<0.05）， had nothing to do with the pathological type（ P>0.05）.The expression of LTB4 had no means with histological type and TNM stage（ P>0.05）， there was a close correlation between IL-27 and LTB4.Conclusion：The expression levels of IL-27 and LTB4 were closely related to pathogenesis and development in lung cancer.Detection simultaneously， There are important significance for lung cancer clinic diagnosis and assessment of the degree of malignancy and prognosis.
2015 Vol. 12 (12): 33-35 [Abstract]（
505
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LI Bai-tao，CHEN Chun-lin，CHEN Li-xing，et al.
Objective：To explore the clinical effect of soft channel minimally invasive technology operation in treating hypertensive cerebral hemorrhage.Method：19 patents with soft channel minimally invasive technology operation in our hospital from April 2013 to July 2014 were chosen as the observation group，and at the same time 19 cases with craniotomy operation were chosen as the control group.The clinical effects of the two groups were compared and analyzed. Result：Compared with the control group， the observation group had obvious advantages on the treatment efficiency， at the same time， the total efficiency after 7 days of the observation group（ 84.2%） was significantly higher than that of the control group（ 63.2%）， the total efficiency after 3 months of the observation group（ 94.7%） was significantly higher than that of the control group（73.7%）， and the obvious differences had statistical significance（ P<0.05）.The nerve function defect degree and the incidence of complications of the two groups were statistically significant（ P<0.05）.Conclusion：The soft channel minimally invasive technology operation has obvious effects on treating hypertensive cerebral hemorrhage，and it is worthy of applications in clinic with the advantages of less nerve nerve function damage and lower incidence of disease.
2015 Vol. 12 (12): 36-38 [Abstract]（
450
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WANG Hu-gen， XU Bin.
Objective：To compare the effectiveness of locking compression plate combined with three different bone grafts autogenous bone， allogeneic bone，and bone morphogenetic protein（ BMP） composite bone for radius and ulna fracture nonunion.Method：From December 2009 to December 2013， 62 cases of eligible of radius and ulna fracture nonunion were randomly treated with autogenous bone（ group A， n=22）， allogeneic bone（ group B， n=23）， and BMP composite bone（ group C， n=17）.The cure rate after 12 months and the Anderson good rate of forearm fractures were compared among 3 groups at different time points.Result：All patients of 3 groups were followed up at least 12 months.The cure rate of groups A and B was signifcantly different（ χ2=5.494，P < 0.05）， but no significant diference was found between groups A，C and B，C （P>0.05）.The Anderson good rate was compared at same period：There were significant difference between the group A and B of each time period（ P<0.05），but no significant difference was found between groups A and C； at 6th and 12th months after operation， there was significant difference between the group B and C（ P<0.05）.Conclusion：The effect of BMP composite bone is equivalent to that of autogenous bone graft in treating nonunion of radius and ulna fracture， and they are better than allogeneic bone graft.
2015 Vol. 12 (12): 41-43 [Abstract]（
610
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LIN Zhi-zhong.
Objective： To investigate the clinical efficacy of clinical patients with Helicobacter pylori positive peptic ulcer 10 day sequential therapy.Method： 90 patients with Helicobacter pylori positive peptic ulcer in our hospital were selected， and randomly divided into experimental group and control group， 45 cases in each group. The control group used the triple therapy of Omeprazole enteric coated capsules 20 mg/times， Amoxicillin 100 mg/times， Clarithromycin 50 mg/times， combined use of drugs， 2 times a day， for 10 days as a course of 1. In the experimental group， 10 day sequential therapy， 5 days ago， to the enteric coated Omeprazole capsule 20 mg/times， Amoxicillin 100 mg/times， 2 times a day. After 5 days， to the enteric coated Omeprazole capsules 20 mg/times， Clarithromycin 50 mg/times， Metronidazole 40 mg/times， the drug combination， 2 times a day， and a total of 10 days to 1 course. After treatment of Helicobacter pylori in two groups of patients， the clinical curative effect of eradication and recurrence rate were observed. Result：（1）After the treatment， the experimental group therapy for Helicobacter pylori eradication situation better than the control group， the difference was statistically significant（ P<0.05）.（2） After the treatment， the patients in the experimental group the total effective rate was significantly better than the control group，the difference was statistically significant（ P<0.05）.（ 3）After treatment， the experimental group the recurrence relapse rate was significantly lower than that of the control group， the difference was statistically significant（ P<0.05）. Conclusion： The effect of 10 day sequential therapy in Helicobacter pylori positive peptic ulcer treatment significantly， can promote ulcer healing， so as to improve clinical symptoms， reduce relapse rate.
2015 Vol. 12 (12): 44-47 [Abstract]（
517
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CHEN Chen， FANG Xing-gen.
Objective：To perform a cost-utility analysis of intracranial aneurysms patients who combined hyperbaric oxygen treatment after surgery.Method：From September 2012 to September 2014， data of 112 patients who underwent intracranial aneurysms surgeries and hyperbaric oxygen n treatment（ HBO group） and data of 112 intracranial aneurysms patients who only took traditional treatment（ the control group） were collected in our hospital， evaluated by the ability of daily life（ADL） scale.Cost-utility analysis were performed between the two groups.Result：The ADL scale of the two groups both increase after treatment， the ADL scale of HBO group was higher significantly compared to the control group（P<0.01）.The cost per QALY of the HBO group was less than the control group， especially for the patients with Hunt-Hess Ⅲ-Ⅳ grade.Conclusion：For aSAH patients underwent intracranial aneurysm surgery， treated with HBO in addition to the traditional treatment， could achieve the maximization use of medical resources， deserves further promotion.
2015 Vol. 12 (12): 47-49 [Abstract]（
476
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WANG Gen-mei，LIU Yan-e，MAI Xiu-mei，et al.
Objective：To investigate the diagnosis of perineal ultrasound in elderly female pelvic morphologic observation and pelvic floor dysfunction. Method：From August 2010 to March 2014 in our hospital treatment of 80 patients with pelvic floor dysfunction were selected， and divided into SUI group（ 48 cases） and POP group（ 32 cases）， the control group with similar age， selection of parity and body mass index of the women in 40 cases. The ultrasonic detection results of two groups were compared. Result：The Valsalva state， M in urinary incontinence group， organ prolapse group was significantly higher than the control group（P<0.05）， and anal contraction state， M in organ prolapse group was significantly higher than the control group， the difference was statistically significant（ P<0.05）. The resting state， A in urinary incontinence group， organ prolapse group significantly higher than those in the control group， the difference was statistically significant（ P<0.05）； Valsalva， A in urinary incontinence group， organ prolapse group was significantly higher than the control group（P<0.05）， and anal contraction state， A in organ prolapse group was significantly higher than the control group， the difference was statistically significant（ P<0.05）. Conclusion：The clinical value of perineal ultrasound for elderly female patients with pelvic morphologic observation and pelvic floor dysfunction is higher， it is worthy of popularization and application.
2015 Vol. 12 (12): 50-53 [Abstract]（
656
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CHEN Jin-song，LIN Gui-xi，YAO Jian.
Objective：To evaluate the efficacy and safety of Donepezil combined with Paroxetine at acute cerebral infarction in the treatment of post-stroke depression.Method：79 patients with post-stroke depression were randomly divided into two groups from October 2012 to July 2014， among which 41 cases as experimental group， and 38 cases as control group.Experimental group was treated with Donepezil.It was 5 mg/d within the first 14 days.Additionally，20 mg Paroxetine was given once a day for 90 days.Control group was only treated with 20 mg Paroxetine was given once a day for 90 days.The degree of neurological deficit was compared using the Hamilton Depression Scale（HAMD）and modifies Rankin Scale（mRS）scoring between the two groups after treatment respectively.Result：Hamilton Depression Scale was significantly improved，and the modifies Rankin Scale were significant enhanced in the experimental group when compared with the control（P<0.05）.No serious adverse reaction occurred during treatment.Conclusion：Donepezil combined with Paroxetine at acute cerebral infarction which has a higher security probably improves the prognosis and reduces the disability of patients with post-stroke depression.
2015 Vol. 12 (12): 53-55 [Abstract]（
572
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HAN Hui，LIU Jian-bo，YANG Pei-wen，et al.
Objective：To explore the etiology structure and therapeutic effect of chronic cough in Dongguan Changping area.Method：Totally 120 patients with chronic cough were diagnosed using a diagnostic protocol based on the guideline on diagnosis and treatment of chronic cough established by Chinese medical association and the american college of chest physicians， which included clinical manifestation， auxiliary examination and empirical treatment effect.The curative effect was judged after specific treatment and drug withdrawal 4 weeks.Result：The cause of chronic cough was confirmed in 112 patients（ 93.3%）， with a single cause found in 104 patients.The top 5 important single cause of cough were：cough variant asthma（CVA）， upper airway cough syndrome（UACS）， gastroesophageal reflux（ GERC）， postinfection cough（PIC）， atopic cough（AC）.After specific therapy based on diagnosis， cough disappeared in 30 patients （25.0%）， alleviated in 75 patients（62.5%） and had no changed in 7 patients（5.8%）.Conclusion： CVA， UACS and GERC are the most common causes of chronic cough in Dongguan changping area.Specific therapy based on definite cause can result in a good outcome.
2015 Vol. 12 (12): 56-59 [Abstract]（
543
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ZHONG Zhi-hui， MO Wei-feng， LIANG Jian-tao，et al.
Objective：To analyze the inter-beam and a concave iliopubic ligament in pediatric laparoscopic hernia repair application effect.Method：100 cases of pediatric inguinal hernia from September 2012 to March 2014 in our hospital were randomly divided into two groups，50 cases of each group.The control group received inner laparoscopic ligation，the observation group received iliopubic tract and interfoveolar ligament suture on the basis of control group.Treatment and relapse rates of the two groups were observed.Result：The two groups’ operation time， hospital stay and postoperative ambulation time had no significant difference（ P>0.05）.The complication rate of the observation group was 4.0%， significantly lower than the 14.0% of the control group（P<0.05）.The relapse rate of the observation group was 0， significantly lower than 10.0% of the control group（ P<0.05）.Conclusion：Pediatric hernia inner mouth horizontal bars appear around the peritoneal defect， and sutured iliopubic tract and interfoveolar ligament will help reduce the defect part of the peritoneum horizontal bars on the inner mouth ligation programs should be more firmly this method effectively reduces concurrency disease and relapse rates， should be introduced.
2015 Vol. 12 (12): 59-61 [Abstract]（
658
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CAI Xue-jian，CHEN Yuan-xin， HUANG Jian，et al.
Objective：To explore incision and drainage of the cisterna magna influencing the cathetering time of lateral ventricle drainage， in the treatment of hypertensive cerebellar hemorrhage breaking into ventricle.Method：10 patients with hypertensive cerebellar hemorrhage breaking into ventricle who were received and cured in our hospital and People’s Hospital of Dongguan from July 2014 to January 2015， received posterior fossa craniotomy evacuation of hematoma while using incision and drainage of the cisterna magna（ treatment group）， and infused lateral ventricle and cisterna magna with urokinase postoperatively， recorded the cathetering time of lateral ventricle drainage； the original patients with posterior fossa craniotomy hematoma removal of foramen magnum decompression and lateral ventricle drainage were selected as control cases（ control group）.Result：The mean catheterization time of lateral ventricle drainage was（ 4.00±2.49）d， in treatment group， while（ 7.30±2.00）d in control group， The difference had statistical significance（ t=3.270， P<0.05）.Conclusion：Cisterna incision drainage shorten the mean catheterization time of lateral ventricle drainage in the treatment of hypertensive cerebellar hemorrhage breaking into ventricle， so reducing the infection rate of intracranial， and improving the curative effect.
2015 Vol. 12 (12): 62-65 [Abstract]（
536
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LI Li，DENG Ying-ying，OU Hai-juan.
Objective：To explore the fat in a role in the treatment of children with neonatal hypoxic ischemia encephalopathy.Method：120 children with HIE were selected as the research object， the patients were randomly divided into two groups， the experimental group of patients on the basis of routine therapy used ganglioside treatment， control group children take regular treatment.The curative effect of patients after treatment， clinical symptoms returned to normal time and so on were investigated.Result：After treatment，the effect was obviously improved， the recovery time of clinical symptom was shorten， and DQ scores was improved， serum NSE levels was lower too of the experimental group， compared with the control group differences were statistically significant（ P<0.05）.Conclusion：The ganglioside in the treatment of neonatal hypoxic ischemia encephalopathy has obvious clinical effect， can improve the effect of clinical treatment， is worth further promotion and use.
2015 Vol. 12 (12): 65-67 [Abstract]（
453
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LIU Fei，CHEN Wei-ming，CHEN Gui-quan，et al.
Objective：To explore the method and effect of skin and soft tissue defect of thumb flap repair.Method：60 cases of skin and soft tissue defect of thumb were selected in our hospital in recent two years received as the research object， with the different treatments will be divided into the observation group， the study group and the control group three groups， 20 cases in each group， the observation group underwent free skin flap in repairing treatment， study group treated with flap repair treatment， the control group underwent pedicled repair treatment， the treatment of patients with three groups.Result：The results of this study show that the observation of patients in the treatment group the excellent and good rate was 80.0%， the treatment of patients in the study group the excellent and good rate was 75.0%， control group was treated with the excellent and good rate was 85.0%； three patients in treatment group had no significant difference compared to the excellent rate（ P>0.05）， no statistical significance.Conclusion：Skin and soft tissue defect of thumb with skin flap repair treatment should be to patients with thumb defect degree and medical level as a basis to choose the best method to repair， as far as possible to restore the function of the thumb and the appearance of the patients.
2015 Vol. 12 (12): 67-69 [Abstract]（
483
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CUI Li-juan， FAN Ai-hua， LIAN Xiu-qun.
Objective：To study the influence of hyperbaric oxygen on microcirculation， erythrocyte deformation and TCD changes after cerebral of hyperbaric oxygen.Method：60 cases of patients with cerebral infarction in our hospital from January 2013 to December 2013 were selected randomly， they were divided into study group（ n=30） and control group（ n=30） according to the treatment methods.The control group were given drug therapy alone， while the study group were given medication therapy combined with hyperbaric oxygen therapy.Result：Compared with the control group， the total conjunctival microcirculation integration of the study group was significantly higher（ P<0.05）， the ipsilateral ACA，MCA， BA were significantly lower（ P<0.05）， the ESS score was significantly lower（ P<0.05）， the Barthel index was significantly higher（ P<0.05）， the total treatment efficiency 96.7%（ 29/30） was significantly higher than the control group 53.3%（ 16/30）（P <0.05）. Conclusion：Hyperbaric oxygen has some impacts on microcirculation， erythrocyte deformation and TCD changes after cerebral， but it combined with medication therapy can improve the patients’ neurological deficit， improve the activities of daily living， has a significant effect.
2015 Vol. 12 (12): 70-73 [Abstract]（
572
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LIU Yong，LUO Hui-xian，CHEN Wan-qu，et al.
Objective：To observe the clinical effect of Dexmedetomidine for elderly patients undergoing total hip replacement.Method：60 elderly patients with total hip replacement were selected and randomly divided into 3 groups，20 cases in each group.Patients in group A received a 4 μg/mL Dexmedetomidine intravenous infusion of 10 min，maintaining 0.2 g/（kg·h）； patients in group B received a 4 μg/mL Dexmedetomidine intravenous infusion of 10 min，maintaining 0.4 g/（kg·h）； patients in group C received a 0.9% Sodium Chloride Solution.The he heart rate（ HR）， mean arterial pressure（ MAP） and oxygen saturation（ SpO2） level of 3 groups were observed and recorded before and after anesthesia， intraoperative and postoperative.The propofol dosage and awake time of 3 groups were recorded， respectively. At the same time， pain degree was measured by using visual analogue scoring system（ VAS）.The incidence of adverse reaction were observed after operation.Result：After anesthesia， the patients in the B group SPO2 was significantly lower than that of A group and C group， the difference was statistically significant（ P<0.05）.The patients in the B group of propofol dosage is lower than that of A group and C group（P<0.05）. The patients in the A group VAS were lower than those of B group and C group（P<0.05）. Hypoxemia in patients in the B group were higher than A group and C group（P<0.05）. Conclusion：Dexmedetomidine for elderly total hip replacement， sedative effect significantly， the respiratory inhibition is lighter and less adverse reaction.
2015 Vol. 12 (12): 73-76 [Abstract]（
568
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JIANG Zhi-gao， YANG Qian-zhao， MA Wen-xue， et al.
Objective：To explore the relationship between cardiac autonomic function and blood pressure circadian rhythm in diabetic hypertensive patients.Method：70 essential hypertensive patients were recruited， 35 complicate with diabetes as the experimental group（ group EH-DM） and the other 35 with normal blood glucose as the control group（ group EH）.They underwent standard cardiovascular autonomic function tests（ SCAFT） and ambulatory blood pressure monitoring（ABPM）.Result：The SCAFT score was higher in the group EH-DM than in the group EH P<0.05）.The decline of SBP at night（ΔSBP%）was lower in the group EH-DM than in the group EH（P<0.05）.The ratio of non-dipping circadian rhythm in the group EH-DM was higher than that in the group EH（ P<0.05）.The decline of SBP at night and SCAFT score appeared in an obvious negative correlation（r=-0.328，P<0.05）.Conclusion：The diabetic hypertensive patients have higher SCAFT score and higher ratio of non-dipping circadian rhythm.Blood glucose may affect blood pressure circadian rhythm through impairing cardiovascular autonomic function.
2015 Vol. 12 (12): 76-79 [Abstract]（
470
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YANG Ye，TANG Lin-guo，CHEN Gui-lan，et al.
Objective：To analyse the eugenic adverse factors exposure among fertile couples，and explore the importance of health education in preconception care.Method：A total of 563 fertile couples were investigated with questionnaires.The correlating items were：general condition，family history，history of diseases，adverse factors exposure in working and living environment， life style and pattern of behaviour， Social psychological factors，et al. Result：The order of adverse factors women exposed was：frequently usage of cellphone，hair drier，hair coloring，perm or hair treatment，working with computer and watch TV frequently.The order of adverse factors their spouses exposed was：frequently usage of cellphone，smoking and alcohol. Conclusion：It’s not so popularization of preconception care in Guangzhou suburb district.It’s very important to spread health education widely，and to guide fertile couples avoiding adverse factors exposure which could cause birth defects or adverse pregnancy outcome.
2015 Vol. 12 (12): 80-83 [Abstract]（
397
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PENG Hai-jing，GUO Jia-hua，ZHONG Yu-hong，et al.
Objective：To study the feasibility and clinical effects of clinical nursing pathway in pre-hospital emergency care of patients with cerebral apoplexy.Method：A retrospective analysis was carried out on clinical information of 53 cases of patients with cerebral apoplexy， who were rescued and transported from March 2013 to December 2013. These 53 patients were given regular nursing and were assigned into the control group.53 cases of patients with cerebral apoplexy were given pre-hospital emergency care by clinical nursing pathway from January 2014 to November 2014. These 53 patients were assigned into the observation group.Los Angeles Pre-hospital Stroke Screen（ LAPSS） was used to screen two groups of patients with cerebral apoplexy.The two groups of patients were compared in the duration from clinical reception to rescue， the duration from rescue to professional treatment， length of hospital stay and mortality. Result：Average duration from clinical reception to rescue， average duration from rescue to professional treatment and length of hospital stay in the observation group were all significantly shorter than those of the control group（ P<0.05）.47 cases were survival（ 88.68%） while 6 cases（ 11.32%） died in the observation group.39 cases were survival（ 73.58%） while 14 cases（ 26.41%） died in the control group.And there were significant differences between the two groups of patients in survival rate（ P<0.05）.Conclusion：Clinical nursing pathway is feasible for pre-hospital emergency care of patients with cerebral apoplexy， which can guide the pre-hospital emergency care and improve the survival rate and prognosis of patients.
2015 Vol. 12 (12): 84-86 [Abstract]（
688
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ZHOU Hui-zhen，HUANG Li-yun，CAI Wei-xiong.//
Objective：To investigate the nursing experiences of vacuum sealing drainage（VSD） in the treatment of anterior tibial bone exposure.Method：40 patients with anterior tibia bone exposure treated with VSD were received the comprehensive nursing including psychological intervention，wound surface nursing, drainage tube nursing， and so on.The postoperative wound repair， healing of fracture and nursing satisfaction were observed.Result：After VSD treatment and comprehensive nursing care， 40 patients were reached the wound repair and bone healing.The satisfaction rate of nursing skills and nursing attitude was 97.5%， 95.0% respectively.Conclusion：VSD combined with comprehensive nursing care in treatment of anterior tibial bone exposure have obvious effect and high nursing satisfaction， is worth the clinical promotion.
2015 Vol. 12 (12): 87-89 [Abstract]（
565
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SHEN Min，WAN Li-xin.
Objective：To analyze and explore the clinical application effects of community intervention in diabetic patients with hypertension.Method：300 elderly diabetic patients with hypertension from March 2012 to June 2014 from 10 communities under our jurisdiction were selected as the research objects and divided into two groups with 150 cases each. Patients of the control group were given regular medication， while patients of the observation group were given community intervention.Clinical effects of the two groups of patients were observed.Result：Clinical results showed that there were statistically significant differences between the observation group and the control group in total effective rate and cognitive rate of diseases（P<0.05）； there were statistically significant differences between the observation group and the control group in treatment compliance， diet self-control， weight control， quit rate of smoke and drink， and regular examination，etc（P<0.05）； blood sugar of the observation group before and after intervention was better than that of the control group and the differences between the two groups were of statistical significance（P<0.05）.Conclusion：Community intervention in diabetic patients with hypertension can improve the clinical cure rate and quality of life and reduce the incidence of complications， which is worthy of promotion and application.
2015 Vol. 12 (12): 90-92 [Abstract]（
650
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XIE Bo，CHEN Si-han， FAN Bei-fang，et al.
Objective：To develop a scale which was able to reflect the dental coping index for children. Method：Combining some items in the dental coping strategy questionnaire， the present study collected items describing the dental coping style for children.By examining these items with schoolchild and adapting factor analysis， a dental coping index scale was compiled， which’s psychometric indexes were examined.Result：11 items were chose to constitute the dental coping index for children.There were moderate correlations among the item score to the scale score，with correlation coefficients distributed 0.38-0.61； there were significant differences between the high 27% score group and the low 27% score group；the dental coping index questionnaire for children consisted of three dimensions， which，s cumulative explanation of the variance 51.07%， with the Cronbach’s α 0.74， and 0.62-0.68 for the subscales.Conclusion：The Dental Coping index Questionnaire for children has satisfactory psychometric characteristics.It is suitable for practical usage.
2015 Vol. 12 (12): 93-96 [Abstract]（
596
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LIU Yu-qiong，WEI Gui-ju，HE Qiu-xian.
Objective：To study relationship and nursing countermeasures of antinuclear antibodies， liver specific autoantibodies with chronic hepatitis B.Method：From March 2013 to March 2014 in our hospital for treatment of 100 cases of patients with chronic hepatitis B（ CHB） as the research object.Chose 92 cases in our hospital received physical examination of normal persons as control group， the related antibodies， CHB from positive and negative group of related indicators， nursing care of patients before and after treatment adherence of two groups were compared. Result：Chronic hepatitis B group’s ANA positive rate was 24.00%（ 24/100）， was significantly higher than the control group’s 4.35% （4/92）， the difference was statistically significant（ P<0.05）.CHB group since the positive resistance layer adhesion proteins（ LN） and hyaluronic acid（ HA）， and collagen type Ⅳ levels were significantly higher than the negative resistance groups， differences were statistically significant（ P<0.05）.Two groups in ALT， AST， HBV quantitative was contrast and HBV parting， there were no statistically significant difference（ P>0.05）.After nursing of treatment adherence for patients with chronic hepatitis B was significantly higher than before treatment， the difference was statistically significant（ P<0.05）. Conclusion：There are more antibody in serum of patients with chronic hepatitis b， but the ANA and the prognosis of patients with liver disease related antibody assay for predicting and outcome has great significance， it could be one of the causes of liver cirrhosis after hepatitis B.At the same time， nursing countermeasures for patients and can increase treatment adherence to care，worthy of clinical attention.
2015 Vol. 12 (12): 97-100 [Abstract]（
515
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LYU Shuang-cong，CAO Rui-li，ZHAO Xi-rong.
Objective：To analyze the causes of inpatient drug withdrawal of our hospital， and to discuss the method of decreasing medicine return.Method：A total of 589 drug withdrawal application since January to June 2014 were analyzed according to the causes， department and medication types of drug return.Result：The patients refused to use was the main cause of drug withdrawal， the frequency was higher in medicine department than in surgical department，anti microbial drugs were in the first place of returned medication because of higher utilization and more adverse reactions. Conclusion：Formulate strict drug withdrawal management system in hospital pharmacy， strengthen communication between medical staff and patients， improve patients compliance with medication.
2015 Vol. 12 (12): 101-103 [Abstract]（
594
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YANG Zhong-ping，LAI Yue-feng，HUANG Shi-qian，et al.
Objective：To improve the overall strength of community health to promote sustainable development，increase reasonable income， focus on solving community health service centers（ hereinafter referred to as community health centers） to carry out site inspection difficult， inconvenient people， improve the quality of medical issues limited. Method：The medical test sites scattered resources to set up its own central laboratory focused on testing， specimen collection sites established， check， storage， transportation， centralized testing， the results of the operation of the system feedback such as a complete package， exploring a fixed pattern.After the election from November 2013 to October 2014 site inspection to detect the number of resource integration and economic income were selected for the study group.Detecting the number and economic integration between income before election as the control group from November 2011 to October 2012， and the differences were observed.In addition， patients and medical staff satisfaction survey after integration，satisfaction surveys， quality of medical care and community health centers to improve the overall strength of the assessment methods were studied.Result：Integration site medical test innovative models to increase resources and reasonable income，quality of care， and physician satisfaction of the people had been greatly improved.After statistical analysis， the two groups were 89.0% satisfaction and 72.0%， the difference was statistically significant（ P<0.05）； the study group was higher income， single item test of time than the control group， there were significant differences（ P<0.05）.Conclusion：Social health center integration site dispersed medical laboratory resources can improve community health comprehensive strength of promoting sustainable development， this new mode of operation can increasing the economic income， reduce the individual test cost， significantly improve the satisfaction and the quality of medical treatment， is higher application value.
2015 Vol. 12 (12): 104-106 [Abstract]（
583
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LI Xin-ying，YAN Cai-li，ZHONG Hui-ting.
Objective：To explore the effect of centralized sterile supply mode for common items（e.g wet bottle，treatment plate， tourniquet）in preventing hospital infection，and to provide scientific guidance for improving the quality of management.Method：Hospital infection status in January to June 2014（ taken medical supplies common centralized sterile supply mode，marked as experiment group）and July to December 2013（not token medical supplies common centralized sterile supply mode，marked as control group） were retrospective analysis ，and cleaning pass rate and cost-effective cleaning differences before and after used centralized sterile supply mode were compared and analyzed. Result：The pass rate of commonly used items cleaned of control group was 94.2%， experiment group was 100%，the difference was statistically significant（ P<0.05）.The medical supplies costing of control group was（ 22.0±2.0） thousands RMB， experiment group was（ 15.0±1.0）thousands RMB， the difference was statistical significance（ P<0.05）. Conclusion：Centralized sterile supply mode for common items can effectively prevent hospital infection rates， can improve medical quality， can reduce the amount of the spread of contamination， can reduce medical supplies costing，so it is worth to promote in hospital.
2015 Vol. 12 (12): 107-109 [Abstract]（
571
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HUANG Sui-hua，JIANG Ling， DENG Jie-fang.
Objective：To investigate the prophylactic effect of antifungal therapy in patients with severe chronic obstructive pulmonary disease（COPD）. Method：140 patients with COPD in our hospital were divided into two groups randomly.The control group were received routine therapy， the observation group were given routine treatment combined with fluconazole therapy.The pulmonary fungal infection rate at different ages and different clinical scale of two groups were compared.Result：In patients at 70-80 ages， the fungal infection rates were 0（ 0/40） and 15.00%（6/40） in treatment group and control group respectively， with a significant difference between two groups（ P<0.05）.At very severe scale patients， the fungal infection rates of treatment group and control group were 0（ 0/36） and 15.38%（ 6/39） respectively，with a significant difference between two groups（ P<0.05）.Compared the fungal infection rates in patients at aged 60-70 （0 vs 2.50%） and at severe scale（ 0 vs 2.44%） of two groups， the differences were not statistically significant（P>0.05）. The incidence of adverse reactions between the two groups had no significant difference.Conclusion：Early application of antifungal treatment on COPD patients at 70-80 ages or at very severe clinical scale， has a preventive effect， and no obvious adverse reaction.
2015 Vol. 12 (12): 110-112 [Abstract]（
542
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WEI Peng-tao， HAN Xing-tao，ZHANG Han，et al.
Objective：To summarize the application of PCNL on complex renal calculus treatment. Method：253 patients with complex kidney stones during the period from October 2006 to August 2014 were analyzed. The patients were treated with the method of percutaneous nephrolithotomy. The operation skills，the complications of surgery and the corresponding treatment measures were summarized. Result：Patients were all cured，and 55 cases were fever of postoperative，after anti-infection treatment cured；10 cases of blood transfusion，2 cases of massive hemorrhage，14 cases of pleural effusion，and 4 cases of seroperitoneum. Conclusion： PCNL is the effective method for kidney stones，when there is difficulty through established channels，Multi-tract PCNL without increased incidence rate of bleeding or infection，which deserves a wider application.
2015 Vol. 12 (12): 113-116 [Abstract]（
585
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FENG Wen-jie，WANG Xiao-yu.
Objective：To explore the clinical characteristics of Ann Ⅲ class wrong occlusal deformity in our hospital.Method：100 cases of Ann Ⅲ such wrong occlusal deformity were selected from May 2013 to May 2013， and the clinical characteristics were treated and analyzed.Result：Wrong occlusal male 45%， female 55%， male and female sex ratio had no difference（ P>0.05）.Individual teeth dislocation（ 28%）， anterior teeth crowding accounted for 22%， deep overburden occlusal accounted for 17%， deep super occlusal accounted for 15%， the occlusal accounted for 13%， the blade occlusal accounted for 3%， open occlusal accounted for 1%，the other 1%.Conclusion：Make Ann Ⅲ class wrong occlusal deformity flow clinial study， can provide accurate reference basis for clinical prevention and treatment， in order to ensure overall oral health.
2015 Vol. 12 (12): 116-118 [Abstract]（
600
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XUE Yu-hua，LI Lian，OUYANG Gui-ping.
Objective：To investigate β-serum human chorionic gonadotroPin（ β-hCG） estradiol（ E2） and Progesterone（ P） the determination of the early diagnosis of ectopic pregnancy， ectopic pregnancy conservative treatment selection and therapeutic value.Method：150 cases of ectopic pregnancy were selected as the group A， 100 cases of normal intrauterine pregnancy were selected as the group B.Theβ-hCG， E2 and P were determined by chemiluminescence. According to β-hCG， E2， P content in the blood， given conservative medical treatment， determined β-hCG， E2， P ectopic pregnancy treatment options significance.Compared successful conservative treatment group decreased serum β-hCG and P levels were within the normal range to the time required.The different of pre-treatment serum β-hCG，E2 and P levels and treatment outcome relationship were analyzed. Result：The serum β-hCG ，E2 and P in the group A were lower than the group B， the differences were statistically significant（ P<0.05）.Conservative treatment decreased serum P drug levels to normal less than the time required β-hCG drops to normal time required， the lower the P， E2 level， the success rate more high.Conclusion：Serumβ-hCG， E2 and the level of P is helpful to early diagnosis of ectopic pregnancy； serum P determination is a dynamic detection effect of conservative treatment of ectopic a superior evaluation of serum β-hCG of pregnancy； according to the content of blood β-hCG， E2， P for the treatment of early ectopic pregnancy options provide quantitative indexes.
2015 Vol. 12 (12): 119-122 [Abstract]（
781
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GAO Yan，ZHENG Jing-leilei，LIU Yu-sheng，et al.
Objective：To study the therapy effect on chest keloid based on skin soft tissue expansion under keloid. Method：29 chest keloid patients were randomly divided into two groups， the skin expander was buried under the keloid in group A， while under the normal skin around the keloid in group B.Then both of the groups received regular water injection treatment to expansion.After reoperation to remove the dilator and to resect the keloid， radiotherapy continued for 5 days.The total length of the operation scar was measured， and the cases of complication and recurrence followed up for 6 months -2 years were counted， and the difference between the both groups was compared.Result：The total length of operation scar was（ 7.68±1.30）cm in group A while the length was（ 10.25±2.05）cm in group B， which had significant difference（ P<0.05），but complications and recurrence rate of two groups had no statistical difference（ P>0.05）. Conclusion：Tissue expansion under the cicatrix has the advantages of safer，less trauma and less operation scar for chest keloid.
2015 Vol. 12 (12): 122-125 [Abstract]（
463
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ZHANG Zi-gang，LIU Tie-zhu，XI Xiao-long.
Objective：To assess the clinical efficacy of laparoscopic microwave ablation（ LMA） in the treatment of small renal carcinoma.Method：From May 2012 to Oct 2014， the LMA was performed for 15 small renal carcinoma. The renal pedicle was not blocked during operation， microwave ablation was carried out for tumors smaller than 3cm，while laparoscopic microwave ablation partial nephrectomy（LMAPN） was performed for tumors 3-4 cm.The operation time， blood loss， changes of Hb， SCr and GFR before and after operation， postoperative hospital stay， complication rates and tumor prognosis of these cases were recorded and analyzed.Result：All cases were operated successfully， no case was converted to laparotomy.There was no significant change of Hb， SCr and GFR after operations（P>0.05）.The operation time was（ 103±15）min， the blood loss was（ 72±25）ml， the postoperative hospital stay was（ 5±2）d. The complication rate was 13.3%（2/15）， with 1 case of fever and 1 case of pain with no case of urine leakage.Patients were followed up for 18.7（6-32）months.Enhanced CT was taken by 1 month，3 month and 6 month after operation，there was no tumor recurrence and death cases. Conclusion：LMA for small renal carcinoma is safe and effective with less bleeding，quick recovery and low complication rate.It is hopefully to become one of an effective way for treating T1 stage renal carcinoma.
2015 Vol. 12 (12): 125-128 [Abstract]（
353
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LYU Hui-juan，ZHU Lu-wen，TANG Qiang.
Multiple sclerosis is a chronic inflammatory demyelinating central nervous system disease，inflammatory mediators and inflammatory cell inflammatory cell infiltration cause brain damage， and then cause nerve dysfunction.Review the mechanism of action of this article on the inflammatory reaction in patients with multiple sclerosis.
2015 Vol. 12 (12): 129-131 [Abstract]（
527
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WANG Li-jia，CHENG Rui-ying，LIU Jie.
The past 30 years， diabetes prevalence rate increased significantly in China.Type 2 diabetes is often associated with multiple cardiovascular risk factors hyperglycemia，obesity and dyslipidemia，clustering of these risk factors can contribute directly to atherosclerosis and the occurrence and development of cardiovascular disease， seriously affecting the health of patients， is the main cause of death in patients with diabetes.The proportion of overweight and obesity increased significantly， has become one of the causes of diabetes epidemic. Obesity and diabetes mellitus macroangiopathy have a close relationship， where the adipose cells secrete adipokines may be the connection between the two bond.Recently discovered adipokines chemerin may be involved in glucose and lipid metabolism pathway through a variety of ways. Therefore， this article aims to analyze the relationship between chemerin and diabetes mellitus macroangiopathy.For early detection， early diagnosis and early treatment of diabetic macrovascular provide ideas.
2015 Vol. 12 (12): 139-142 [Abstract]（
489
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WANG Jiao， SUN Li-yuan.
Remote ischemic conditioning（ RIC） refers to an endogenous therapeutic strategy， including remote ischemic preconditioning and remote ischemic postconditioning， which has a promising prospect in clinical application. And it has the advantages of security、none-invasive、convenience and economical. More research confirmed that RIC have protective effect on cardiovascular and cerebrovascular disease， cardiovascular surgery and organ transplant surgery. In this article， we briefly review the history of the neuroprotective effect of remote ischemic conditioning in cerebrovascular disease.
2015 Vol. 12 (12): 143-146 [Abstract]（
790
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DING Yun-fei， SUN Shu-guang，LIU Xiao-mei.
Diabetes is characterized by chronic hyperglycemia metabolic diseases. with the improvement of people's living standards， the aging population， the incidence rate was gradually rising trend. Diabetes pathogenesis is still not very clear so far， and pathogenesis of diabetes is now a hot topic. Interleukin-4（IL-4）（ 10kb） located on chromosome 5q31.1， there are four polymorphic alleles. which has a strong linkage disequilibrium. In this paper， the correlation progress（ IL-4） gene polymorphisms of interleukin-4 with type 1 diabetes， type 2 diabetes， diabetes complications start on.
2015 Vol. 12 (12): 150-153 [Abstract]（
605
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